Systems Approaches Evolve Clinical Pharmacology

Systems Approaches Evolve Clinical Pharmacology

The May 2013 issue of Clinical Pharmacology and Therapeutics (CPT),1 coincident with the recent launch of the new journal CPT: Pharmacometrics and Systems Pharmacology (CPT:PSP),2 highlights systems approaches in pharmacology. These publications underscore the concept that we have reached a critical juncture in the discipline of clinical pharmacology.3 Until recently, the field was driven by a ...

Leveraging systems biology approaches in clinical pharmacology

Computational modeling has been adopted in all aspects of drug research and development, from the early phases of target identification and drug discovery to the late-stage clinical trials. The different questions addressed during each stage of drug R&D has led to the emergence of different modeling methodologies. In the research phase, systems biology couples experimental data with elaborate c...

Integrative Systems Approaches Towards Brain Pharmacology and Polypharmacology

Polypharmacology is considered as the future of drug discovery and emerges as the next paradigm of drug discovery. The traditional drug design is primarily based on a ”one target-one drug” paradigm. In polypharmacology, drug molecules always interact with multiple targets, and therefore it imposes new challenges in developing and designing new and effective drugs that are less toxic by eliminat...

Clinical Pharmacology

Clinical Pharmacology